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Vanda CEO Mihael Polymeropoulos called the drug a familiar therapeutic agent that offers flexible dosing with a well-known safety profile. April 1 Product: AstraZenecas Voydeya Indication: Paroxysmal nocturnal haemoglobinuria AstraZeneca kicked off April with a win for its rare disease portfolio as the FDA approved Voydeya, an oral, first-in-class factor D inhibitor to treat a subset of patients with paroxysmal nocturnal haemoglobinuria (PNH)
A: Compounded formulations offer customizable concentrations (e.g., minoxidil above 5%), alternative delivery vehicles for patients with sensitivities, ingredients not available commercially as topicals (finasteride, dutasteride, spironolactone), and multi-agent combinations that address multiple hair loss mechanisms in a single application
AHAs and BHAs: Alpha hydroxy acids like glycolic acid and beta hydroxy acids like salicylic acid create low-pH environments that can destabilize copper peptide structures
Theoretical concerns exist about copper peptides and certain cancers, as copper is involved in angiogenesis
Response: We appreciate the commenters' support for our proposal
